生物相关合成高分子在溶液和固体中降解的控制因素《ACS Applied Bio Materials》

Factors Controlling Degradation of Biologically Relevant Synthetic Polymers in Solution and Solid State

Jordan Brito, Alexander K. Andrianov*, and Svetlana A. Sukhishvili*

Department of Materials Science & Engineering, Texas A&M University, College Station, Texas77843, United States

ACS Appl. Bio Mater. 2022, XXXX, XXX, XXX-XXX

Publication Date: October 7, 2022

https://doi.org/10.1021/acsabm.2c00694

REVIEW

Abstract

The field of biodegradable synthetic polymers, which is central for regenerative engineering and drug delivery applications, encompasses a multitude of hydrolytically sensitive macromolecular structures and diverse processing approaches. The ideal degradation behavior for a specific life science application must comply with a set of requirements, which include a clinically relevant kinetic profile, adequate biocompatibility, benign degradation products, and controlled structural evolution. Although significant advances have been made in tailoring materials characteristics to satisfy these requirements, the impacts of autocatalytic reactions and microenvironments are often overlooked resulting in uncontrollable and unpredictable outcomes. Therefore, roles of surface versus bulk erosion, in situ microenvironment, and autocatalytic mechanisms should be understood to enable rational design of degradable systems. In an attempt to individually evaluate the physical state and form factors influencing autocatalytic hydrolysis of degradable polymers, this Review follows a hierarchical analysis that starts with hydrolytic degradation of water-soluble polymers before building up to 2D-like materials, such as ultrathin coatings and capsules, and then to solid-state degradation. We argue that chemical reactivity largely governs solution degradation while diffusivity and geometry control the degradation of bulk materials, with thin “2D” materials remaining largely unexplored. Following this classification, this Review explores techniques to analyze degradation in vitro and in vivo and summarizes recent advances toward understanding degradation behavior for traditional and innovative polymer systems. Finally, we highlight challenges encountered in analytical methodology and standardization of results and provide perspective on the future trends in the development of biodegradable polymers.

KEYWORDS:

• biodegradation

• biomaterials

• autocatalysis

• degradable polymers

• hydrolysis

• controlled release

SUBJECTS:

• Degradation,

• Diffusion,

• Materials,

• Polymer degradation,

• Polymers