pH响应高分子纳米颗粒用于药物递送《Macromolecular Rapid Communications》

pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram, Changhe Zhang, Sarah S. Kermaniyan, Angus P. R. Johnston, Georgina K. Such

School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia

Macromolecular Rapid Communications, Volume40, Issue10

Special Issue: Functional Natural and Synthetic Polymers

First published: 05 March 2019

https://onlinelibrary.wiley.com/doi/full/10.1002/marc.201800917

REVIEW

Abstract

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.

摘要

刺激响应性纳米颗粒具有改善治疗药物向体内特定细胞或区域递送的潜力。有许多刺激物显示了货物特定释放的潜力，包括pH值的变化、氧化还原电位或酶的存在。pH变化对刺激响应性纳米颗粒的合成产生了极大的兴趣，因为纳米颗粒通过酸化的囊泡内化到细胞中。此外，已知肿瘤微环境的pH值低于周围组织。在这篇综述中，讨论了设计pH响应纳米颗粒的不同策略，重点是电荷转移聚合物、酸不稳定键和交联的应用。