海鞘诱导的具有抗菌活性的超分子纤维素纳米复合水凝胶《ACS Biomaterials Science & Engineering》

海鞘诱导的具有抗菌活性的超分子纤维素纳米复合水凝胶

摘要

超坚韧水凝胶的设计最近成为科学界非常感兴趣的话题，因为它们具有模仿生物组织特征的能力。制备这些材料的杰出策略依赖于水凝胶基质内的可逆和动态交联。在这项工作中，受海鞘外衣组成的启发，可拉伸超分子水凝胶结合了聚乙烯醇、绿茶衍生的没食子酸和刚性鞣酸包覆的纤维素纳米晶体(TA@CNC)设计。添加TA@CNC浓度高达1.2wt%的纳米填料由于促进了与聚合物基质的氢键作用和多酚π–π堆积相互作用，显著影响了水凝胶的机械和粘弹性。这些超分子缔合赋予水凝胶优异的拉伸性和强度（>340%，540 kPa）、低热可逆凝胶-溶胶转变（60°C）和重塑能力，而天然多酚提供了潜在的抗菌性能。这些通用材料有望为合理设计用于不同生物医学应用的多酚基纤维素水凝胶开辟新的前景。

Ascidian-Inspired Supramolecular Cellulose Nanocomposite Hydrogels with Antibacterial Activity

Anabela Carnicero, Agustín González, Sergio D. Dalosto, Mario C. G. Passeggi Jr., Roque J. Minari, Cecilia I. Alvarez Igarzabal, Marisa Martinelli*, and Matías L. Picchio*

Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), CONICET, Güemes 3450, Santa Fe 3000, Argentina

Departamento de Química Orgánica, Facultad de Ciencias Químicas (Universidad Nacional de Córdoba), IPQA−CONICET, Haya de la Torre y Medina Allende, Córdoba X5000HUA, Argentina

ACS Biomater. Sci. Eng. 2022, XXXX, XXX, XXX-XXX

Publication Date: November 1, 2022

https://doi.org/10.1021/acsbiomaterials.2c00935

EMERGING TRENDS

Abstract

The design of ultratough hydrogels has recently emerged as a topic of great interest in the scientific community due to their ability to mimic the features of biological tissues. An outstanding strategy for preparing these materials relies on reversible and dynamic cross-links within the hydrogel matrix. In this work, inspired by the composition of ascidians’ tunic, stretchable supramolecular hydrogels combining poly(vinyl alcohol), green tea-derived gallic acid, and rigid tannic acid-coated cellulose nanocrystals (TA@CNC) were designed. The addition of TA@CNC nanofillers in concentrations up to 1.2 wt % significantly impacted the mechanical and viscoelastic properties of the hydrogels due to the promotion of hydrogen bonding with the polymer matrix and polyphenols π–π stacking interactions. These supramolecular associations endow the hydrogels with excellent stretchability and strength (>340%, 540 kPa), low thermoreversible gel–sol transition (60 °C), and remolding ability, while the natural polyphenols provided potential antibacterial properties. These versatile materials can be anticipated to open up new prospects for the rational design of polyphenol-based cellulosic hydrogels for different biomedical applications.

SUBJECTS:

• Gelation,

• Hydrogels,

• Nanocomposites,

• Phytochemistry,

• Stress