具有可控疏水相互作用的发光金纳米粒子《Nano Letters》

具有可控疏水相互作用的发光金纳米粒子

摘要

在第二近红外窗口（NIR-II）中具有高度红移发射和良好生物相容性的发光金纳米颗粒（AuNP）的构建仍然具有挑战性。在本文中，使用具有不同形式的单体和胶束中可控疏水相互作用的两亲性嵌段共聚物（ABC）模板，我们报道了一种用于红移发光和增强发光AuNP的生物相互作用的简便策略。虽然均匀的NIR-II AuNP团簇在ABC胶束的疏水核内原位形成，具有较强的粒间疏水相互作用和1080nm的增强发射，量子产率（QY）为1.6%，但刚性的NIR-IIAuNP在表面上以ABC单体的形式具有较强的颗粒内疏水相互作用，导致1280nm的红移发射，QY为0.25%。这些发现为设计具有增强生物相互作用的高红移发光AuNP开辟了新的可能性。

Luminescent Gold Nanoparticles with Controllable Hydrophobic Interactions

Bing Tang, Wenle Xia, Wei Cai, and Jinbin Liu*

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China

Nano Lett. 2022, 22, 20, 8109–8114

Publication Date: October 10, 2022

https://doi.org/10.1021/acs.nanolett.2c02486

Abstract

The construction of luminescent gold nanoparticles (AuNPs) with highly redshifted emission in the second near-infrared window (NIR-II) and good biocompatibility is still challenging. Herein, using an amphiphilic block copolymer (ABC) template with controllable hydrophobic interactions in the diverse forms of unimers and micelles, we report a facile strategy for redshifting the emission and enhancing the biological interactions of luminescent AuNPs. While the uniform clusters of NIR-II AuNPs are formed in situ inside the hydrophobic cores of ABC micelles with strong interparticle hydrophobic interactions and enhanced emission at 1080 nm with a high quantum yield (QY) of 1.6%, the rigid NIR-II AuNPs are generated with strong intraparticle hydrophobic interactions as ABC unimers on the surface, leading to a redshifted emission of 1280 nm with a QY of 0.25% and enhancing the affinities toward injured intestinal mucosa in colitis imaging. These findings open new possibilities for the design of highly redshifted luminescent AuNPs with enhanced biological interactions.

KEYWORDS:

• luminescent gold nanoparticle

• hydrophobic interaction

• emission

• redshift

• imaging

SUBJECTS:

• Hydrophobicity,

• Luminescence,

• Metal nanoparticles,

• Micelles,

• Molecular mechanics