聚吡咯有序超大介孔立方体用于白蛋白的可控包封和释放《Nano Letters》

聚吡咯有序超大介孔立方体用于白蛋白的可控包封和释放

摘要

尽管近年来在多孔材料方面取得了重大进展，但具有连续大孔的导电聚合物（CPs）的可控制备仍具有挑战性，这对于储能、电催化和生物分离等多种应用非常重要。在这里，我们使用软模板策略开发了一种前所未有的有序双连续介孔PPy立方体（mPPy-cs），获得了∼45nm的超大介孔和高比表面积69.5m²g^–1。mPPy-cs具有可调节表面电荷和对pH值敏感的独特特性，在30分钟内表现出接近定量的白蛋白吸附，从而能够有效地从商业白蛋白产品中的典型内含物免疫球蛋白G中分离。此外，通过降低pH值，吸附的白蛋白可以以受控方式进一步释放。这项工作为定制孔径和纳米结构的自底向上构建CPs提供了一种可行的策略，有望引起人们对其性质和应用的极大关注。

关键词：聚吡咯 介孔聚合物 自组装 双连续型 蛋白质分离

Polypyrrole Cubosomes with Ordered Ultralarge Mesopore for Controllable Encapsulation and Release of Albumin

Yong Wu, Jing Cui, Yang Ling, Xinyue Wang, Jianwei Fu, Chengbin Jing, Jiangong Cheng, Yanhang Ma, Jinyao Liu*, and Shaohua Liu*

State Key Laboratory of Precision Spectroscopy, Engineering Research Center of Nanophotonics and Advanced Instrument, Ministry of Education, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, P.R. China

Nano Lett. 2022, 22, 9, 3685–3690

Publication Date: April 21, 2022

https://doi.org/10.1021/acs.nanolett.2c00330

Abstract

Despite substantial progress in porous materials over past years, controllable preparation of conductive polymers (CPs) with continuous large pores is challenging, which are important for diverse applications, including energy storage, electrocatalysis, and biological separations. Here, we develop an unprecedented ordered bicontinuous mesoporous PPy cubosomes (mPPy-cs) using a soft-template strategy, resulting in ultralarge pores of ∼45 nm and high specific surface area of 69.5 m2 g–1. Along with their unique characteristics of adjustable surface charges and sensitivity to pH, mPPy-cs exhibited a near quantitative adsorption of albumin within 30 min, enabling efficient separation from immunoglobulin G, a typical inclusion in commercial albumin products. Moreover, the absorbed albumin could be further released in a controlled manner by lowering the pH. This work provides a feasible strategy for bottom-up construction of CPs with tailored pore sizes and nanoarchitectures, expected to attract significant attention to their properties and applications.

KEYWORDS: polypyrrole, mesoporous polymer, self-assembly, bicontinuous structure, protein separation

来源：《Nano Letters》

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